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Another GLP-1 analogue, lixisenatide, was reported to prevent the acuteness of cardiovascular events in apolipoprotein E / insulin receptor substrate 2 +/ (APOE / irs2 +/ ) mice by reducing the size of AS plaques, increasing plaque stability, and promoting the conversion of macrophages to the anti-inflammatory M2 phenotype (129)

Exenatide extended-release (Bydureon BCise): 2 mg once weekly for type 2 diabetes

Nature 499 , 444449 (2013) Wootten, D., Simms, J., Miller, L

Postprandial effects of a whey protein-based multi-ingredient nutritional drink compared with a normal breakfast on glucose, insulin, and active GLP-1 response among type 2 diabetic subjects: a crossover randomised controlled trial

This distribution breadth of GLP-1R further highlights the diversity and importance of its biological functions

Components of the incretin and insulin systems also play a role in venomous species, which capitalize on the rapid and debilitating effects of low blood glucose when targeting prey