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In 2011, Hanahan and Weinberg identified several hallmarks of cancer, including autonomous cell proliferation, insensitivity to antiproliferative signals, evasion of destruction by the immune system, stimulation of inflammation, resistance to cell death, replicative immortality, induction of angiogenesis, activation of tissue invasion and metastasis, reprogramming of energy metabolism, and genomic instability and mutation (Fig

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