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Deoxycarnitine, a member of the trimethylamine group, serves as a precursor metabolite of trimethylamine N-oxide (TMAO)

Antunes Dos Santos A, Ferrer B, Marques Gonalves F, Tsatsakis AM, Renieri EA, Skalny AV, Farina M, Rocha JBT, Aschner M (2018) Oxidative stress in methylmercury-induced cell toxicity

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These enzymes are deemed essential for neutralizing harmful free radicals and maintaining cellular integrity

Damaged AECs release pro-inflammatory and pro-fibrotic mediators, including interleukin (IL) -1 and tumor necrosis factor (TNF) -, which promote fibroblast recruitment, inflammatory cell activation (e.g., neutrophils, Th17, gdT cells), and myofibroblast differentiation, ultimately leading to ECM accumulation and fibrotic tissue remodeling [20, 29, 33, 34]