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Metabolic derangements, including hepatic lipids and the development of Type 2 diabetes mellitus An accumulation of fat at least 5% of the liver weight is considered the onset of MDAFL, and the grade of MASLD is grouped according to the accumulated percentages of fat (Chalasani et al

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Importantly, metabolic syndrome is a significant risk factor for several common cancers (e.g., liver, colorectal, breast, endometrium, pancreas) 4,5

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KO) mice have decreased neuronal GSH concentrations in the brain 8,9,10