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These findings elucidate the substantial role of simvastatin in enhancing gastric cancer immunotherapy through ILF3, thereby providing a theoretical basis for the synergistic use of statins in immunotherapeutic applications

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2022 Jul 2;22(1):724

The inhaled silica particles can be directly phagocytosed by alveolar macrophages (AMs), and thereby triggers NLRP3 inflammasome activation and IL-1 production, which results in a cascade release of proinflammatory and profibrotic cytokines, i.e., IL-6, tumor necrosis factor (TNF-) and TGF-1

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