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Specifically, the use of GLP-1RAs results in a reduction in BP (reduction in systolic BP by 1 mmHg with lixisenatide and by 5.4 mmHg with semaglutide) through a natriuretic and vasodilatory effect, likely mediated by the atrial natriuretic peptide, released as a result of binding to specific receptors expressed in the atria [43]

Ongoing vomiting, severe constipation, or significant weight loss beyond expectations warrant medical guidance

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Mounjaro (tirzepatide): Patients taking the 15 mg dose lowered their hemoglobin A1C (a way to measure blood sugar over time) by 2.4% in some studies

The groups that started at 4 mg experienced significantly more nausea, vomiting, and diarrhea than those who began at 2 mg

Preclinical studies have demonstrated that GLP-1 receptor agonists reduce neuroinflammation, reduce tau phosphorylation, reduce amyloid deposition, increase synaptic function, and improve memory formation