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Many patients find that setting hourly reminders or using a water bottle with time markers helps them reach their daily fluid goals consistently

Lancet 2018;392:13841386

While metformin has historically been the treatment of choice in first-line therapy, guidelines now recommend a patient-centered approach with any mono- or combination therapy that allows patients to maintain treatment goals [14]

Ryan DH, Yockey SR (2017) Weight loss and improvement in comorbidity: differences at 5%, 10%, 15%, and over