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Lack of clinical therapeutic benefit of antidepressants is associated overall activation of the inflammatory system

A high-fat diet increases gut microbiota biodiversity and energy expenditure due to nutrient difference

N Engl J Med 352:16851695 Ridker PM (2016) From C-reactive protein to interleukin-6 to interleukin-1: moving upstream to identify novel targets for atheroprotection

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Facial thinness, reduced puffiness around the jawline and cheeks, and changes in how clothing fits frequently show up before total body weight moves much, because early change reflects reduced water retention as well as fat loss