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In 1983, it was found to be a cleavage product of proglucagon processing and secreted by intestinal epithelial endocrine L cells (17)

So a molecule that seems to talk directly to fibroblasts, and that the body stocks less of with age, is an obvious candidate for the microscope

Bjerre Knudsen L, Madsen LW, Andersen S et al

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Biomedicines 10

Liraglutide, a widely used GLP-1RA in clinic, ameliorated the macrophage accumulation in periodontitis, by decreasing M1 macrophages but not M2 macrophages (30 g/kg/day) (34)