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Some patients respond exceptionally well to GLP-1 monotherapy, while others may need the additional mechanisms of dual or triple agonists

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Affectionately called 'Lizzie, or Gilly' by diabetic patients and marketed as 'Byetta', exenatide was the first slow-release GLP-1 mimic to reach the market (Schuler, Shearin)

Compared with disulfide-based systems, which are widely used due to their simplicity and predictable cleavage by intracellular GSH, diselenide linkages offer greater redox sensitivity and can respond to both GSH and ROS