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Data availability The source data for all the graphs in main figures in Supplementary Data 1

ACSL4 knockout downregulated lipid peroxidation and inhibited ACSL4/p38 MAPK/GPX4 pathway-mediated ferroptosis, ultimately inhibiting NAFLD progression [194]

Rare but serious risks include pancreatitis, thyroid C-cell concerns (primarily animal data), and retinopathy in diabetic patients

Tissue Repair & Regeneration Support BPC-157 is widely studied for its role in: Tendon and ligament healing Muscle recovery and regeneration Joint and connective tissue repair 2

Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum

990,991,992 A randomized, blind, placebo-controlled crossover study (NCT013655104) has found that DFO increases plasma erythropoietin and VEGF concentrations, resulting in significant time- and age-dependent improvements in cerebrovascular reactivity in the elderly