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Serious side effects are rare but may include elevated liver enzymes or gallbladder issues

Updated December 22, 2025

Briefly, in these 16-hour overnight sessions one lever (e.g., left or right) was available and a 10% sucrose reward was offered starting at a fixed ratio of 1 (FR1) for every lever press which escalated to FR4 by the end of the session

Stopping the medication often leads to the return of appetite and potential weight regain

Artificial sweeteners: Sorbitol, mannitol, xylitol, and maltitol have osmotic effects that draw water into the intestines

Therefore, this population might need earlier and more aggressive treatment than other groups with MASLD [56]