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[26] [27] Retatrutide could potentially be considered for this route given its novel mechanism, though no ILAP designation has been announced and eligibility would need to be assessed formally by the MHRA

Similar findings were reported for glucagon/GLP-1 dual agonists, where increased fatty acid oxidation in white adipose tissue contributes significantly to energy expenditure [32, 33]

The body has already adapted to GLP-1 receptor activation, which can mean less intense initial side effects but potentially a delayed perception of "new" appetite suppression

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A daily multivitamin and mineral supplement is commonly recommended for individuals on significantly reduced calorie intakes, though it should complement not replace a varied diet