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Separation was achieved using a gradient of Solvent B (10 mM TEABC, pH 8.0, 90% ACN) and Solvent A (10 mM TEABC, pH 8.0) at the flow rate of 250 L/min
Additional evidence also indicates that activation of the GLP-1/GLP-1R signaling pathway is implicated in the pathogenesis of sepsis-associated encephalopathy (SAE)
The TIR group received an intraperitoneal dose of 1.35 mg/kg BW for four cycles, expanding upon prior research that identified the neuroprotective properties of the administered dose in diabetic rats (Guo et al., 2023)
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