For most people, the honest answer is no
The majority of the extrahepatic tissues depend on receptor-mediated uptake of SELENOP to maintain adequate selenoprotein expression
However, using liver-specific AMPK knockout mice, Foretz and colleagues demonstrated that metformin lowers gluconeogenesis by an AMPK-independent mechanism involving a decrease in cellular energy state, a strong correlation being observed between the increase in cellular [AMP]:[ATP] and the inhibition of gluconeogenesis (46)
The goal is to create a strong GH pulse that mimics a natural peak and then subsides, which is a different strategy than the nighttime dose often used with Sermorelin to support circadian rhythm
HOW TO USE: Before use, hold the cap facing downward and gently tap the bottom of the tube with your palm to bring the cream toward the nozzle
Blood work showing high LH and FSH naturally (before HCG) suggests primary failure, which responds poorly to HCG