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Production requires a considerable metabolic input from ATP, methyl groups, and specific nutrients, including B vitamins, selenium, and amino acids

Specifically, omega-3 PUFAs and their derivatives exhibit strong anti-inflammatory, anti-nociceptive, and neuromodulatory effects, impacting the pathophysiology of migraines (14, 16, 17)

Therefore, compounders should ensure that all ingredients they use to produce sterile injectable drugs are manufactured under conditions and specifications appropriate for the intended route of administration

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