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Within the nucleus, Nrf2 heterodimerizes with small Maf proteins and binds to cis-regulatory DNA sequences termed Antioxidant Response Elements (AREs)

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Altered PTEN pathway expression has been found to enhance the efficacy of anti-PD-1 and anti-CTLA-4 antibodies in mouse models 60 and to improve the chemoresistance of breast cancer cells to DOX 61