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Abstract Glutathione synthetase deficiency is a rare autosomal recessive disorder resulting in low levels of glutathione and an increased susceptibility to oxidative stress
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Concerning antimicrobial enzymes and phagocytic function, the effects of MPs on LYZ and phenoloxidase (PPO) activities are model-dependent: short-term or low-dose exposure may upregulate LYZ expression and activity, possibly as a compensatory response, whereas other contexts show enzyme inhibition or dysfunction, reflecting the complexity of MPsmicrobiotahost interactions [85]
GSH deficiency can interfere with the body's ability to detoxify the cellular microenvironment, fold proteins, replenish antioxidants, maintain healthy immune responses and even modulate apoptotic events, promoting suboptimal cellular function and development of diseases [53]
