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That gap is why it puts provider oversight ahead of any assumption that two mechanisms simply add up

The brain is a GLP-1 organ GLP-1 and its receptor are expressed in the central nervous system, and several agonists cross the blood-brain barrier to varying degrees (West et al., 2025)

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The strongest evidence-based case for GLP-1 therapy is in patients who have both overweight or obesity and established cardiovascular disease

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This helps lower blood sugar levels and prevent hyperglycemia, a hallmark of diabetes