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Without human PK/PD, there is no established relationship between an administered amount and a plasma concentration, no half-life, no tissue-distribution data, and therefore no rational basis for any human dosing
The MTHFR anomaly is reported out as heterozygous or homozygous
Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes
A doctor might inform the patient that this peptide isnt FDA-approved and we dont have full safety information, but is the patient (especially a layperson desperate for pain relief) really in a position to grasp that they are effectively a test subject
