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This elegant shuttle system serves dual purposes: enabling fatty acid oxidation while preventing excess acyl-CoA accumulation in the cytosol and mitochondrial matrix

This creates a biological ceiling that cannot be overcome by simply adding more input

While body weight increased over time in both the Donor+Cas9-treated and normal diet-fed mice, the Saline group exhibited a more rapid weight gain, resulting in a gradual decline in the relative body weight of the Donor+Cas9 and normal diet-fed groups (Fig

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Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T

No case reports have documented this, but the absence of evidence is not evidence of absence