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In a 2026 JAMA secret-shopper study, a slender Yale medical student posed as a 237-pound patient and attempted to obtain semaglutide or tirzepatide from 49 direct-to-consumer websites

GLP-1 is a naturally occurring hormone in the body that helps regulate blood sugar levels and appetite, which can be stimulated by injectable drugs such as Ozempic and Mounjaro

Summary: Current evidence does not show that GLP-1 receptor agonists directly cause bone loss or increase fracture risk in adults

FDA approval criteria are clear and consistent across approved GLP-1 medications for weight management

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The first incretin to be discovered was glucose-dependent insulinotropic polypeptide (GIP)