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Blocking NNMT is expected to raise SAM availability, but SAM participates in many cellular processes, so research must establish that selectively raising it does not perturb other methylation pathways

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(PMC) Monitoring score Is there a clinician involved who will interpret benefit, side effects, dose, and discontinuation decisions

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In this study, we aimed to analyze senescence during chondrocyte expansion and use senolytics to remove senescent chondrocytes for the enhancement of cartilage formation in ACI