We view the shortage of GLP-1s to be much worse than the official data suggests
GLP-1 In Response to a Meal And that leads right into the second problem: instead of looking at the average number over the entire day, lets take a look at GLP-1 production after a meal
This is the smallest adjustment you can make and carries virtually no additional risk
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Co-treatment of 4d (A2-thio-imidazole derivative), a novel TGR5 agonist, and Sitagliptin (DPP-4 inhibitor) exhibited a GLP-1 secretion and glucose-lowering effect in animal models, while this compound alone exhibits only a slight 1.3-fold increase in GLP-1 secretion [182]
On the other hand, Liraglutide, which requires daily injections, may be more suited to patients who need more immediate effects due to its shorter half-life but are comfortable with daily injections