Tirzepatide is administered subcutaneously once weekly at doses ranging from 2.5 mg to 15 mg, with gradual dose escalation recommended to minimize gastrointestinal adverse effects
This creates a potential risk of pulmonary aspiration during general anaesthesia when protective airway reflexes are suppressed
In terms of safety, it was consistent with previous GLP-1RAs level of safety, with no additional safety concerns identified (Husain et al., 2019)
Likewise, Tonin et al
but after administered with Lactobacillus rhamnosus , the TMAO level was increased, and the TMA concentration in the liver of mice was unchanged ( Streptococcus thermophilus , Lactobacillus acidophilus , and Bifidobacterium longum ) for 3 months, there was no change in TMAO level, but the betaine level in plasma was significantly increased (Table 1) ( TABLE 1 Probiotic/prebiotic that effect TMAO level
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