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Sleep optimization Poor sleep disrupts leptin, ghrelin, and cortisol, the three hormones most directly involved in appetite regulation and fat storage

As pregnant women are typically excluded from clinical trials, their safety for the developing fetus is unknown

It usually emerges from overlapping disturbances across muscle, liver, adipose tissue, gut hormone signalling, and brain insulin sensitivity

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The mean BMI was 32.9 kg/m 2

The SNP-based heritability estimated on the observed scale was 0.78% (SE = 0.04%), which was highly significant (Z = 21.09, P-value = 9.41 10), further supporting a polygenic basis for ovarian cancer