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For example, in atherosclerosis, when macrophage uptake of modified lipoproteins exceeds cholesterol efflux, cholesterol accumulates, leading to the formation of foam-like macrophages (Ye et al., 2019) (Figure 1)

doi: 10.3389/fgene.2022.839154 Received 19 December 2021 Accepted 18 February 2022 Published 13 June 2022 Volume 13 - 2022 Edited by Maritha J Kotze, Stellenbosch University, South Africa Reviewed by Sirimas Kanjanawart, Khon Kaen University, Thailand Chonlaphat Sukasem, Mahidol University, Thailand Updates Copyright 2022 Ferdiana, Fachiroh, Oktarina, Irwanto, Mahendra, Febriana and Soebono

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