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38 These detoxification-related proteins promote metabolic inactivation of APAP, thus protecting the liver from damage induced by NAPQI (Figure 2)

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In the 1980s, it was found that supplementation with sodium selenite could improve chondrodystrophy (Kashin-Beck disease) and juvenile cardiomyopathy (Keshan disease) which were caused by Se deficiency

UV can promote the translocation of Bax to the mitochondria [59], increasing the expression of p53 and Bax, and decreasing the expression of Bcl-2 [60]

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