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Of the factors that participate in the TSS pathway, cystathionine beta-synthase (CBS) and cystathionine -lyase (CSE) mediate the first two rate-limiting steps of TSS by condensing serine with homocysteine to cystathionine and then cysteine

2 Both effectively lower HbA1c, but insulin is often necessary in advanced type 2 or type 1 diabetes

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Workshop participants reviewed the existing evidence and agreed on a simple and realistic set of measures for clinicians and families to record, including changes in hunger, behaviour, gastrointestinal symptoms and routine laboratory results

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