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This complexity is hard to replicate in a synthetic lab

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10.1186/s12931-024-02906-y 38 ZhaoY.XuG.LiH.ChangM.GuanY.LiY.et al (2020)

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If you are taking creatine to support muscle maintenance or growth, ensure your dietary protein intake remains sufficient, typically 1.6 to 2.2 grams per kilogram of body weight daily for those engaged in regular resistance training

Vitamin D deficiency alone affected 7.5% of users at six months