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CYP2E1 is the principal CYP responsible for the metabolism of ethanol and is considered to be a major component of the microsomal ethanol-oxidizing system

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Microbiology 153, 215224

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1 Animal studies The Wegovy SmPC reports that in pregnant rats given semaglutide, the developing pups showed signs of harm at doses lower than those used to treat obesity in humans

Early preclinical animal studies suggest that semaglutide can be absorbed through the tissue under the tongue and may reach measurable levels in the bloodstream, though sublingual semaglutide has yet to be studied in large human weight-loss trials