reducing the risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease
Further medicinal chemistry optimization to improve structure activity relationship and potency as well as safety and toxicity, pharmacokinetic (bioavailability, half-life and biodistribution) and rodent in vivo studies will follow to determine the compounds potential to become suitable candidates for further development
That said, clinicians should be aware of and inquire about sexual side effects
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Understanding the published evidence behind each component helps researchers justify their formulation choice
Some patients experience constipation, which could theoretically increase intra-colonic pressure and potentially trigger diverticulitis symptoms, though there is no established clinical evidence directly linking these medications to diverticulitis flare-ups