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Melanotan-2 remains the only available pharmacological tool allowing the simultaneous study of the relative contributions of the four MCR receptors using selective antagonism protocols (HS024 for MC4R, JNJ-10229570 for MC3R, etc.)

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Studies utilising this concentration monitor biomarkers such as ALT/AST and hepatic proton density fat fraction (PDFF)

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Other approaches have entailed limiting the renal clearance of GLP-1- or exendin-based compounds by covalent fusion of the peptide to a large, stable plasma protein like albumin (albiglutide) (51) or the Fc domain of IgG (dulaglutide) (52)

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