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Persistent and uncontrolled oxidative stress and exacerbating NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome activation during severe COVID-19 disease (Lage et al., 2022), induce production of pro-inflammatory cytokines, such as IL-1 and IL-18, that can be explained because of sharply decreased macrophage GSH intracellular levels associated with increased GSH efflux (Zhang T

[DOI] [PMC free article] [PubMed] [Google Scholar] 87

Archived from the original on 4 March 2016

doi: 10.3389/fphar.2020.00239

PMID 9546215

Although the construction will be a nuisance, the result should make for a net positive, said Beth Blauer, Hopkins vice president of public impact initiatives