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Dickinson CJ

Use within 28 days after first puncture

Cycle Guidelines Common Cagrilintide Research Cycle Lengths Approach Short cycle Duration 16 weeks Review Point Week 16 Notes Reaches maintenance just as titration completes Approach Standard cycle Duration 26-32 weeks Review Point Week 26 / 32 Notes Matches Phase 2 trial durations Approach Long cycle Duration 68 weeks Review Point Week 68 Notes Matches REDEFINE 1 and REDEFINE 2 endpoints Cycle length is a research planning choice, not a treatment recommendation

Companion Supplies & Routine Support Cagrilintide + Tirzepatide Dosage Chart This Cagrilintide + Tirzepatide dosage chart summarizes the staggered tirzepatide and cagrilintide weekly titration phases shown in the dosing section above

Take one (1) tablet daily with a meal

NICE has not yet issued guidance on either agent, as appraisal processes are typically initiated only after regulatory approval, although scoping can occur earlier