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Research reveals that senescent cells show upregulation of pro-apoptotic initiators PUMA and BIM while anti-apoptotic guardian BCL-2 is reduced, suggesting these cells are ready to undergo apoptosis but the execution is restrained by the FOXO4-p53 interaction

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Early continuous inhibition of group 1 mGlu signaling partially rescued dendritic spine abnormalities in the Fmr1 knockout mouse model for fragile X syndrome [133]