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Injection technique, peptide structure, and volume all play a role

Promotion of Angiogenesis: BPC-157 activates vascular endothelial growth factor (VEGF) and nitric oxide (NO) pathways, stimulating new capillary formation and improving blood supply to damaged tissues

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A classic example is curcumin, which has an oral bioavailability of less than 1% due to its low solubility in water, which makes it difficult to dissolve and absorb in the gastrointestinal tract, as well as its rapid chemical degradation at intestinal and hepatic pH [52]