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Figure 1 2.1 Overproduction of ROS One hallmark feature of IBD is the overproduction of ROS, which causes dysregulation of signal transduction, an inflammatory response, and DNA damage, all of which contribute to the progression and deterioration of the disease ( 2), nitric oxide (NO), hydroxyl radical (-0H), hydroperoxyl radical (O 2 H), hydrogen peroxide (H 2 O 2 ), and singlet oxygen ( 2.2 Damage to biomolecules ROS can damage various cell biomolecules, including lipids, proteins, and DNA

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[1] That program is complete, but a completed Phase 3 program is not an approval and that gap is where most of the confusion in this comparison lives

However, some may require more time, depending on individual health conditions and the severity of their deficiency

Functionally, butyrate and ISRIB significantly lowered cellular ceramide content (Fig