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Initially, pre-proghrelin undergoes cleavage to generate proghrelin, which is then cleaved at the C-terminal by the enzyme prohormone convertase 1/3 (PC1/3) to yield fully mature ghrelin (24)

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The new drugs will almost certainly be more expensive than those already on the market, but they should make it slightly easier for patients to access older GLP-1 drugs

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10.1016/j.chom.2013.09.012 114 WongC