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Add chronic stress, like tight work deadlines, relationship issues, financial pressure, and you introduce cortisol , your main stress hormone, into the mix
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Xu J, Sato S, Okuyama S, Swan RJ, Jacobsen MT, Strunk E, Ikezu T (2010) Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice