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Institutional review board statement The human studies were approved by the Institutional human ethics committee, CIUSSS de lEstrieCHUS, Universit de Sherbrooke (Approval Number 2022-4415)

It remains the first-line therapy and the standard of care for all patients with PBC, irrespective of liver fibrosis stage ( UDCA is a hydrophilic bile acid naturally found in small quantities (approximately 3%) within human bile

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Expedited review (for urgent situations) takes 72 hours but is rarely granted for weight-loss medications