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Early Phase 2 data of trevogrumab (anti-GDF8/anti-myostatin) with semaglutide suggest half (51%) of the muscle mass lost by Semaglutide alone could be preserved with the addition of trevogrumab
Large portions are also problematic because gastric emptying is slowed smaller, more frequent meals work better
With the accumulation of more science, guidance on these topics may evolve
But they can strengthen a case for medical necessity in borderline situations, support off-label prescribing decisions, and help providers make more nuanced clinical judgments
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