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Comparable to other peptides linked to fatty acids (e.g., the insulins detemir and degludec, the GLP-1RA liraglutide and semaglutide), the fatty acid side chain allows binding to albumin after subcutaneous injection, slows enzymatic degradation and prolongs biological half-life (5760)

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Our findings demonstrated that both natural and synthetic GLP-1 administration altered heat sensitivity and that local administration of GLP-1 notably reduced heat sensitivity and CAP-induced spontaneous pain behavior

10.1038/s41569-021-00605-5 80 ShahS

For many patients on the weight-loss medications known as GLP-1s (glucagon-like peptide-1s), such as semaglutide, tirzepatide and liraglutide, the question of when or whether to stop is inevitable