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doi:10.1155/2020/3142874

However, there is not much evidence that they are altered in vivo by DPP4i and there have been no adverse reactions or safety issues caused by off-target effects of DPP4i on other endogenous substrates [46,47]

"GLP-1 [glucagon-like peptide] is a naturally occurring hormone that helps regulate blood sugars, diet, and appetite," explains Libu Varughese, MD, an endocrinologist and the medical advisor for Aeroflow Diabetes

It is also being shown to increase fatty acid mobilization

Mechanisms differ, and they can be synergistic

But Reuters noted that the process has faced criticism since some drugs cleared under this pathway have later been proven ineffective.