Compounds with 0 and higher solubility value are highly soluble, those in the range of 0 to 2 are soluble, those in the range of 2 to 4 are slightly soluble and insoluble if less than 4
To verify the obtained results, the virulence of the applied virus suspensions (ARBO-virus infected) was also tested by inoculation of brain suspensions prepared from the mice which had been previously treated with NaBPC157 or saline and survived (NaBPC157) (despite virus application) or spontaneously died (saline), respectively
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A structural explanation for these findings was provided from our previous cryo-EM structures of CT(Pro32) and rAmy(Tyr37)-bound AMYRs structures where the bulky phenolic side chain of Y37 rAmy forms perpendicular stacking interactions with W79 ECD 15 , and additional interactions with the respective RAMP protomer that are likely important for selectivity of rAmy for AMYRs over CTR
