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Resistance to paclitaxel-based therapies is the primary reason this malignancy ranks as the leading cause of cancer-related mortality in men and the second highest cause in women (Park et al., 2016

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(2012) Structure-activity characterization of sulfide:quinone oxidoreductase variants

[10] Due to the risk of adrenal insufficiency and other serious adverse effects, oral ketoconazole should only be used to treat serious fungal infections when no other antifungal therapies are available