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LEAN (Liraglutide Efficacy and Action in Nonalcoholic Steatohepatitis), 14 a phase 2 study in 52 patients with biopsy-confirmed MASH, was the first to show the efficacy of a GLP-1 receptor agonist in treating MASH

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848 Resveratrol may improve I/R injury by activating SIRT3/FOXO3a pathway, which increases the expression of catalase and SOD2 and inhibits the production of ROS, thereby reducing lipid peroxidation and ferroptosis