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Koh S, Dupuis N, Auvin S (2020) Ketogenic diet and neuroinflammation

Get the details in the Drinking Water section of our CL Answer about PFAS

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While IV and oral NAD+ therapies can boost systemic levels, topical application offers a targeted approach delivering NAD+ precursors like niacinamide and NMN directly to the skin, where energy production, DNA repair, and antioxidant defense are most needed

It is a cofactor in DNA synthesis and in both fatty acid and amino acid metabolism

Much of its human evidence comes from outside the United States and from a single research lineage a combination that places epithalon firmly outside the category of established, approved therapeutics