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doi: 10.1016/j.diabet.2018.12.001

(PubMed) Liu LL, Wang LN

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7.5 Understand the Patent-to-Formulary Connection Patent expiration and the arrival of generic or biosimilar competition is the single most significant formulary event in any drugs commercial lifecycle

At commercial scale for a product like tirzepatide, where demand is measured in tonnes of API annually, the solvent consumption, waste treatment requirements, and energy intensity of traditional SPPS create sustainability pressures that regulators, investors, and manufacturers themselves are increasingly recognising as material

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