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mice lacking prolactin receptors showed a significant reduction in adipose tissue mass and the number of adipocytes ( in vitro experiments have shown that prolactin receptor (PRLR) gene expression is significantly upregulated during the differentiation of preadipocytes into mature adipocytes, with an approximately 90-fold increase, supporting the functional role of prolactin signaling in adipocyte development and lipid accumulation ( In rodent models, pathological hyperprolactinemia also significantly affects brown adipose tissue (BAT), manifested as the downregulation of thermogenic markers, BAT whitening, and impaired adaptive thermogenesis

Cells 10 , 2844 (2021)

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Delayed approach: Add muscle preservation peptides after several months when muscle loss becomes apparent on body composition testing